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Possession for personal research purposes is generally not prosecuted, though sale for human consumption violates regulations

A randomized crossover study comparing SL-APO and SC-APO found no significant difference in motor improvement (MDS-UPDRS Part III score) but reported greater patient preference for SL-APO due to ease of administration and satisfaction [150]

This plant has demonstrated hypotensive effects in rats

In glaucoma, mitochondrial Zn accumulation induces depolarization, increased permeability and fission, including mPTP opening and mitochondrial fragmentation occurring before retinal ganglion cell apoptosis 156

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