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Several studies suggested a more rapid transport mechanism for selenate than selenite (Arvy, 1993

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However, Ectopic adipocity induced insulin receptor dysfunction of peripheral tissues (cutaneous tissue and skeletal muscle) and that of visceral organs is central to initiation of Insulin resistance followed by hyperinsulinemia

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12 Cellular swelling, karyolysis, karyorrhexis, vacuolization, inflammation and release of cellular contents (alanine aminotransferase, ALT) are key processes of hepatocyte necrosis and related death in humans, as shown by the biochemical evidence of severe elevations in aminotransferases, especially ALT