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Nitric oxide inhibits methionine synthase activity in vivo and disrupts carbon flow through the folate pathway

Intravenous iron infusion therapy results in a faster improvement in hemoglobin levels in the early weeks of treatment compared to oral iron supplements, which can cause gastrointestinal discomfort

Without human trial data, clinicians and patients are making decisions based on incomplete information, and the self-reported adverse effect profile anxiety, palpitations, insomnia, fatigue is not benign enough to ignore

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