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31 Because serine is required (1) for the conversion of folic acid to its active form, (2) as a shuttle for methyl groups between the cytosol and the mitochondria, and (3) as a cofactor in the transsulfuration pathway of methionine/homocysteine metabolism, supplementation with betaine should be included with folic acid, cobalamin, and P5P to optimize the interrelated pathways of homocysteine metabolism

In another study, PD patients with badly controlled motor symptoms were intravenously administrated 1400 mg of glutathione three times a week for four weeks

(b) Quantification of relative S 209 phosphorylation levels

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The present model was also compared to the human LTC4S structure (PDB ID: 2UUH) in Supplementary Fig

10.1002/biof.1171 149