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The inhibition of SGLT2 decreases the expression of HIF-1 in human proximal tubules under hypoxic conditions, leading to a reduction in tubular damage and interstitial fibrosis (274, 275)

Reynolds J

This gene modulation isnt limited to muscles and tendons

January 1, 2006 2006;24(1):6-8

It has been found that microbial metabolites from the gut are not only regulators of inflammation but also the initial instructions for reprogramming the energy metabolic pathways of lung immune cells (such as macrophages and neutrophils)