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3D uniaxial mechanical stimulation induces tenogenic differentiation of tendon-derived stem cells through a PI3K/AKT signaling pathway

In this case, the enzyme -glutamylcyclotransferase catalyzes the conversion of -glutamyl-L-cysteine to 5-oxoproline, favoring the occurrence of 5-oxoprolinuria, chronic metabolic acidosis and neurological disorders (Figure 2) [22]

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This leads to the accumulation of oxidative stress products (e.g., 8-isoprostane), which exacerbates inflammation, damages airway epithelial cells and pulmonary macrophages, and impairs mucociliary clearance function ( Oxidative stress further suppresses the antioxidant system