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Based on the data acquired from the blank samples, the ASV table was further modified by a sample decontamination step that was carried out with the package decontam (Davis et al., 2018) and 0.0088% of sequences were identified as potential contaminations and eliminated (i.e., DNA extraction blanks and experimental controls)

IGF-1 LR3, like native IGF-1, has a tendency to aggregate in neutral aqueous buffer

StatPearls [Internet]

Thrombin and factor Xa link the coagulation system with liver fibrosis

These findings suggest that MitoQ and DPI are more tolerated in an in vivo immunodeficient environment, but their limited efficacy in reducing tumor burden may arise from challenges linked to oral administration, including poor absorption and first-pass metabolism