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In case of adverse effects, the Institutional Review Board would have been notified and, if necessary, the study stopped

The selenocysteine is encoded by the UGA codon, which normally signals translation termination

Another experiment in male rats exposed to aspartame at low (75 mg/kg bw) or high (150 mg/kg bw) doses showed a reduction in the levels of SOD, CAT, GPx, and GSH in the liver (Hamza et al., 2019)