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INSM1: A highly sensitive marker for primary and metastatic Merkel cell carcinoma, superior to SOX11, pancytokeratin, and CK20

A role for RAGE in this response through A binding interaction ( High-mobility group box-1 (HMGB1) HMGB1, also known as amphoterin, is a nuclear protein that binds chromosomal DNA, various transcription factors, tissue-type plasminogen activator (tPA), urokinase-type plasminogen (uPA) activator and plasminogen (139)

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KEGG enrichment analysis revealed that the core pathways were primarily associated with inflammatory response and oxidative stress, including the PI3K-Akt signaling pathway, MAPK signaling pathway, Chemokine signaling pathway, Chemical carcinogenesis - reactive oxygen species, TNF signaling pathway, Th17 cell differentiation, mTOR signaling pathway, and IL-17 signaling pathway (Fig

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