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Goal: Maximize sperm production while on testosterone therapy Approach: HCG 500 IU subcutaneously every other day Consider adding FSH or HMG if response insufficient after 3 months Semen analysis at baseline, 3 months, and 6 months Timeline: Initial testosterone response: 2-4 weeks Sperm appearance: 3-4 months Significant count improvement: 4-6 months If conception remains the urgent priority, discontinuing TRT while increasing HCG to 3000 IU every other day accelerates recovery

In those with cirrhosis, admission lactate 2-4 mmol/L was associated with increased in-hospital mortality compared with lactate 4 mmol/L was associated with increased in-hospital mortality in both cirrhosis (p 4 mmol/L was associated with increased need for RRT during hospitalization in both the cirrhosis (p 65 (p 2 mmol/L, supporting the continued use of this as a cutoff for septic shock definition

& Kromer, L

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Compound 23 is combining the structural elements from Ang IV and the physiological substrates vasopressin and oxytocin

Collectively, this study and others that are conducted with this global team of experts focused on unraveling the biological mechanisms of konzo operates at the highest standards of inclusion, ethical considerations, participant safety and authorship, with the goal of bringing global attention to konzo and other neglected diseases that burden the worlds most impoverished populations