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Use in cerebral edema is not a substitute for careful neurosurgical evaluation and definitive management such as neurosurgery or other specific therapy

For the research context it is key for understanding why amylin analogs do not develop tolerance with chronic use (unlike many other anti-obesity molecules)

Oct 2015;20(110):177-84

For instance, it may affect the activity of enzymes such as hormone-sensitive lipase (HSL), which is one of the key enzymes in the axunge breakdown process and can catalyze the hydrolysis of triglycerides into diglycerol esters and free fatty acids

Treatment is typically recommended for up to two years within this pathway