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On one hand, microglia and astrocytes can mount protective, anti-inflammatory responses, which aid in tissue repair, clearance of damaged cells, and resolution of inflammation [144]

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Cagrilintide monotherapy remains investigational, and the CagriSema combination has been submitted for regulatory review but remained unapproved as of this writing

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However, 24 hour urine measures are representative of total free cortisol production over the course of a day, and while useful in determining the allostatic load experienced by individuals, it is unable to represent the diurnal variation of cortisol expression