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As previously described, INS C94Y pigs gradually develop a diabetic phenotype after birth, because they carry a mutation in the insulin gene, causing insulin misfolding in the endoplasmic reticulum (ER), ER stress leading to beta-cell loss, defective insulin secretion, and persistent hyperglycemia

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10.1139/apnm-2019-0359 [PubMed: 31697573] [CrossRef] Ahmad SY, Friel J, Mackay D (2020b)