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[8] Although not an absolute contraindication, patients with coronary artery disease or unstable angina should only use B-Complex injections containing niacinamide under physician supervision, since high-dose niacin supplements have been linked to arrhythmias in such patients

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The hypertension of D 2 / mice has been related, in part, to increased sympathetic activity, renal oxidative stress, and renal endothelin B receptor (ETBR) expression

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Dosage typically ranges from 5001000mcg daily

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If the protocol lacks precision in dosing, timing, and endpoint measurement, even a mechanistically sound stack will produce inconclusive data

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