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Assessed through medicinal-chemistry optimization and pathway-level translational frameworks

However, one common yet often overlooked reason for fatigue is a deficiency in vitamin B12

This vitamin primarily acts as an enzyme cofactor, helping with DNA and energy production

Patients taking certain medications (e.g., chloramphenicol may reduce the effectiveness of B12 therapy) or with risk factors for B12 deficiency (metformin use, proton pump inhibitors, nitrous oxide exposure, vegan diet) should discuss these with their healthcare provider

You may feel a quick sharp pinch when the needle enters followed by a brief pressure or mild ache in the muscle