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Cotreatment with the ACore resulted in 151% increase in spines per micrometer compared with treatment with A42 only (Dunn's test: p 0.99)

A also stimulates the activation of NADPH oxidases (NOXs), integrin Iib-3, and ROS, promoting platelet adhesion, increasing levels of the endogenous inhibitors plasminogen activator inhibitor-1 and endothelin-1 (ET-1), and resulting in thrombosis, capillary constriction, and impaired blood flow [99, 181, 182]

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