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Interestingly, RIPK1 kinase activation, as marked by its autophosphorylation of S166, was suppressed in the presence of HK2 protein, suggesting that HK2-mediated phosphorylation direct inhibits RIPK1 kinase activation (Fig

The metabolites with shared significance also display the same direction of the change, i.e., the signs of the log fold-changes are identical

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