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Upon consideration of both fluorescent staining results and Tali analyses, we concluded that this caspase-8 activation was not directly related to the apoptosis pathway, but instead was associated with the necrotic death pathway, particularly through the TNF-/caspase-8 axis

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Despite marked structural heterogeneity, these compounds converge upon a shared regulatory network centred on AMPKSIRT1mTORC1, Nrf2ARE, NF-B, PPAR, and FOXO cascades, collectively sustaining cellular homeostasis and longevity