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Based on preclinical (animal and cellular) data only, inhibition of NNMT by 5-Amino-1MQ is theorised to: Raise intracellular NAD+ levels Activate SIRT1 and other sirtuins (proteins linked to metabolic regulation) Reduce fat cell (adipocyte) size and proliferation Improve insulin sensitivity These effects have been demonstrated in mouse models (Neelakantan et al., 2019), but robust human clinical trial data are currently absent

Archived from the original on 19 December 2012

There is no robust body of randomized controlled trial data demonstrating that lipotropic injections cause clinically significant fat loss beyond what the accompanying calorie restriction, activity changes, and clinical monitoring would have produced anyway

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