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NAFLD is associated with increased risk of extrahepatic malignancies

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JNKs, jun amino-terminal kinases

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Dar AA, Fehaid A, Alkhatani S, Alarifi S, Alqahtani WS, Albasher G, Almeer R, Alfarraj S, Moneim AA (2021) The protective role of luteolin against the methotrexate-induced hepato-renal toxicity via its antioxidative, anti-inflammatory, and anti-apoptotic effects in rats

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While the canonical signaling pathways primarily involve the Ras/MAPK and PI3K/AKT cascades, the evolutionary conservation of insulin-like peptides (ILPs) and their pathways hints at the potential for novel functions to emerge over time

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