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The identification, response, and management of potential toxicity and side effects are critical challenges for the clinical application of NPs, which still have a long way to go

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It is delivered via direct scalp injection in a clinical setting

This depletion is tightly linked to the breakdown of immune homeostasis, intestinal barrier dysfunction, and uncontrolled systemic inflammation, underscoring Clostridium s potential as a core target for microbiota-based immunotherapy

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Medicinal chemistry efforts have generated analogs and functional derivatives to address Erastins poor solubility, metabolic instability, and limited usability in vivo (75)