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For observational studies reporting serum vitamin B12 levels, the certainty of evidence was upgraded from low to moderate due to the large and consistent magnitude of effect across studies, despite heterogeneity

doi: 10.2174/0929867323666151127201732 580 MendonaRDCarvalhoNCMartin-MorenoJMPimentaAMLopesACSGeaAet al

doi:10.1016/0304-4165(75)90205-6 42

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When levels are low, that detox process slows down