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Thus, minimizing the proportion of off-targets and checking the possibilities of transgene integration is important for enhancing precise Cas9 endonuclease activity

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By modulating the composition of the gut microbiota in Nrf2-KO mice, particularly by increasing probiotic abundance, it may be possible to enhance resistance to noise-induced tinnitus

11,225 H 2 O 2 is less reactive but selectively oxidizes cysteine residues with low pKa values and reacts with transition metals to generate OH

It is thought that defects in protein transport machinery and regulation, such as RAB1, may play a role in this disease mechanism

doi:10.1016/j.stress.2024.100630