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295 , L379L399 (2008)

A previous study reported that -KG, the metabolite of Glu, is more abundant in Th17 cells than in Treg cells, suggesting that glutaminolysis may be more active in Th17 cells (47).Further mechanistic findings revealed that 2-hydroxyglutarate (2-HG), a direct product of error-prone dehydrogenase activity on -KG, could trigger hypermethylation of the Foxp3 gene and inhibit Foxp3 transcription, thereby inhibiting the differentiation of Treg cells and regulating Th17/Treg homeostasis through epigenetic mechanisms ( Figure 2 ) (48)

The distance from the blood supply can be up to 8 mm or more ( Under normal physiological conditions, the center of the nucleus pulposus primarily relies on anaerobic glycolysis for metabolism, forming a nutrient gradient from the periphery to the center, characterized by a microenvironment with low glucose (approximately 1 mmol/L) and high lactate (approximately 5 mmol/L) (Urban, 2002)

When compared with transcripts of the CK, 644, 1071 and 998 DEGs were characterized in the samples of 1 DPI, 3 DPI and 5 DPI, respectively (Fig

Graves symptoms include anxiety, hand tremors, sensitivity to heat, weight loss, and enlargement of the thyroid gland

BMSCs promote the differentiation of NSCs into oligodendrocytes via mediating Id2 and Olig expression through BMP/Smad signaling pathway