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Notably, certain probiotic species, such as Mobilicoccus massiliensis and Bifidobacterium -derived pentanoate, demonstrate the ability to activate CD8 + T-cells, enhancing anti-tumor responses (101, 112)

Recent studies employing various robust designs such as randomized, prospective, double-blind, placebo-controlled, crossover, comparative, non-randomized, contralateral, interventional, randomized parallel, longitudinal, and investigator-masked approacheshave highlighted the effectiveness of castor oil, derived from Ricinus communis , as a promising therapeutic option for managing a range of ocular surface diseases [328]

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Because MOTS-c involves only 4 injections per cycle, rotate to a different quadrant of the abdomen with each dose to minimize localized tissue irritation