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Our previous finding that pharmacological inhibition of extracellular HMGB1 attenuated NIHL supports the relevance of this pathway, yet how GSDMD is activated by acoustic overstimulation and contributes to HC loss is unknown 13

A negative result may shift attention toward methylation, nutrient status, gut/immune factors, inflammation, or other contributors

The development of tumor treatment strategies targeting GSH-degrading enzymes faces challenges, including different roles of these enzymes in different types of tumor and their impact on the immune response or tumor microenvironment

Host factorssuch as genetics, age, comorbidities, medication use (e.g., antibiotics), immune status, and lifestyle (hygiene, socioeconomic status, occupation)also influence fungal composition 28

Injection sites should remain 1 to 2 inches away from this bony prominence