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Given that LA enlargement is associated with pulmonary hypertension (PH), pulmonary artery muscularization, an indicator of PH, was analyzed in lung sections

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Specifically, for hypothyroidism, all correlations that were significant or non-significant remained so in the subgroup analyses

Since both glucose and fatty acids could contribute to histone acetylation, we reasoned that this could occur either by two distinct substrate-specific mechanisms or a mechanism in which these substrates can feed into a common precursor acetyl-CoA pool (e.g., in mitochondria) that is then transported to the nuclear-cytosolic compartment (Supplemental Figure 5E)

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