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Importantly, it enabled discrimination between human-specific and animal-specific toxicities, such as those induced by bosentan (an endothelin receptor antagonist with known dose-dependent human hepatotoxicity) and fialuridine (an antiviral nucleoside analog that caused fatal human liver toxicity undetected in animals), thereby improving the extrapolation of preclinical findings to human outcomes

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3.5 Renin-angiotensin-aldosterone system In DKD, the activation of renin-angiotensin-aldosterone system (RAAS) is commonly observed and contributes to the progression of DKD

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