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Ferrell JM, Chiang JYL

The pathology of colon revealed the hyperemia and erosion of the mucosa, infiltration of moderate lymphocytes, plasma cells and a small amount of eosinophils and neutrophils in the lamina propria, hyperplasia of lymphoid tissue in the submucosa, suspicious granulomas and suspicious fissure ulcer (Fig

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Notably, XKR8 KO mice exhibited markedly attenuated disease severity compared to WT controls, as evidenced by lower clinical scores and reduced paw thickness (Fig