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doi: 10.3390/biomedicines6020056 188 ChungHLeeYH

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In the Western world, about 90% of megaloblastic anemias result from either alcohol-induced folate deficiency or B12 deficiency [1]

In the cytoplasm, one molecule of glucose can be converted to two molecules of pyruvate via glycolysis that involves a reaction catalysed by 10 enzymes, during which a small amount of ATP and the electron carrier NADH are generated, and pyruvate then enters the mitochondrial matrix and is oxidated by the pyruvate dehydrogenase system to acetyl-coenzyme A (Acetyl-CoA), which generates NADH through the eight steps of the Krebs cycle and participates in the functioning of the ETC, producing ATP and supplying energy for cellular activities ( 3.4 Hypoxaemia Hypoxia is a feature of the synovium in RA

Scientists have used chemical modification techniques to improve the physicochemical properties of NADs

The role of oxidative stress-induced lipid peroxidation in different types of programmed cell death, such as apoptosis (Valko et al