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Studies utilizing metformin reported lower levels of TNF-, S6K, IL-1, and mTOR in the PFC [74, 75]

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FACS analysis confirmed that at passage 10, 54.7% of EpCAM+ HBs co-expressed the proliferative marker Ki67, and immunostaining showed sustained co-expression of AFP, HNF4, and Ki67

Chemotherapy-induced peripheral neuropathy CIPN involves direct neurotoxic damage to dorsal root ganglion neurons, primarily through mitochondrial dysfunction, disrupted axonal transport, and neuroinflammation