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Details for each outcome on the search string used in the systematic review approach, refined inclusion and exclusion criteria, data extraction template and PRISMA diagram are given in Supplementary Information 1

Based upon our rigorous scientific review, in this instance, the strength of evidence of benefits to adult smokers from completely switching to a less harmful product was sufficient to outweigh the risks to youth, said Matthew Farrelly of FDAs Center for Tobacco Products.

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The American Lung Association supports the researchers' suggestion that the FDA do further studies into ventilation holes in cigarettes, said Dr

E-cigarette use has also been linked with pre-symptomatic cardiovascular dysfunction

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