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Hispidulin has been indicated with diverse mechanistic insights in cell cycle arrest: in gastric cancer AGS cells, it sustains NAG-1 (NSAID-activated gene-1) expression through ERK activation, followed by the downregulation of cyclin D1/E, and eventually induces G1/S arrest with apoptosis (Yu et al., 2013

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Additionally, older adults should know the importance of maintaining healthy red blood cells and preventing neurological damage through adequate vitamin B12 intake

10.1111/j.1471-0528.1989.tb01584.x 260 NouriN.Shareghi-OskoueO.Aghebati-MalekiL.DanaiiS.Ahmadian HerisJ.Soltani-ZangbarM

Given the gut microbiota-dependent production of PAGln, we next performed targeted metabolite profiling on plasma and other cardiovascular-related organs