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More reliable is the concentration of B12 in the cerebrospinal fluid, which is almost never measured

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developed a PKM2 allosteric converter (PAC) comprising three functional modules: (1) an allosteric effector module featuring a serine-based motif that bound to PKM2 at Leu-353 and Asp-354, inducing dimer-to-tetramer conversion

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Such association can be attributed due to poor detoxification of RAN/tobacco toxins and lowering c-Jun phosphor-ylation due to its strong binding to JNK which consequently may inhibit apoptosis

de Paula do Nascimento R, Lima AV, Oyama LM, Paiotti APR, Cardili L, Martinez CAR