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This leads to increased release of a peptide called substance P (SP) both centrally and peripherally by nociceptive primary afferent C-fibers

Even though oral supplements can be effective for many people, the absorption rate may vary and be lower than vitamin B12 shots

By administering the fluid through the veins, it allows the therapy to move quickly through your bloodstream providing immediate effects

This makes injections highly effective for pernicious anaemia and other malabsorption syndromes, including post-gastrectomy states, Crohn's disease affecting the terminal ileum, and certain medications that interfere with B12 uptake

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