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H3K4 methyltransferase activity is required for MLL4 protein stability

It is characterized by reduced bone mineral density resulting from alterations in bone microarchitecture, rendering bones susceptible to fractures even under relatively low-impact forces

To bridge the gap between research and clinical application, future efforts should emphasize interdisciplinary collaboration, fostering a seamless transition from understanding the underlying mechanisms to clinical implementation

Commun 5, 4998 (2014)

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These patients usually require a targeted combination of medications and, when needed, interventional procedures that focus on the exact site of irritation (ultrasound-guided blocks, radiofrequency of peripheral branches, or botulinum therapy)