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The models differed substantially in terms of their gene ontology and Kyoto encyclopedia of genes and genomes pathways

doi: 10.1007/s13311-017-0519-x 7 ChenDYuJZhangL

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Prolonged metabolic stress impairs mitophagy and reduces mitochondrial function, as indicated by decreased oxidative phosphorylation, impaired ATP synthesis, and elevated reactive oxygen species (ROS) generation ( Hepatic lipid overload can also directly initiate inflammatory signaling by activating resident immune cells

The science of mast cell stabilization Mast cells sit at the center of allergic disease

Kornmann B, Currie E, Collins SR, Schuldiner M, Nunnari J, Weissman JS, Walter P (2009) An ER-mitochondria tethering complex revealed by a synthetic biology screen