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68-week-old female NCG mice were used to establish the xenograft model by injecting 5 10 4 GBM375-luciferase cells in 2 L of DPBS per mouse at a site 2 mm left and 2 mm anterior to the bregma, at a depth of 3 mm

11, the DFU group (DFU-GP) exhibited significantly elevated levels of matrix remodeling enzymes (MMP-13 and ADAMTS-5) and reduced levels of tissue inhibitor TIMP-3 compared to the normal control (NC-GP)

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