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Glycolysis and supply of glutamine have a pivotal role in UDP-GlcNAc synthesis, as they are obligatory for the rate limiting reaction catalyzed by GFAT

Consistent with these findings, Gene Set Enrichment Analysis (GSEA) revealed enrichment of the SenMayo 30 and ferroptosis pathways in aged oocytes, indicating their transcriptional activation during oocyte aging, which were significantly attenuated by uridine supplementation, thereby reducing senescence-associated transcriptional features (Fig

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