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DOI: 10.1002/14651858.CD010647.pub2

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A vitamin B12 deficiency can lead to symptoms including fatigue, weakness, depression and a swollen tongue or bleeding gums

Genetic factors to consider include: Mutations in the MTHFR gene, which can affect folate and B12 metabolism Variations in genes involved in B12 transport and utilization Understanding these factors helps doctors give better care