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discontinue immediately and seek emergency care if symptoms occur) and fumarates have immunomodulatory effects, effecting a change in the lymphocyte population and a shift from a Th1 pro-inflammatory response to a Th2 anti-inflammatory response

The quantitative analysis of the -H2A.X fluorescence intensity is shown in Fig

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Its dysfunction allows the infiltration of diverse immune cells and systemic markers into the brain parenchyma [190]