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Here, increased mean fluorescence lifetime could represent a switch from free to bound NADPH and NADH species described to experience a longer lifetime ( AKT is a key regulator of various cellular processes including cell proliferation and survival ( To challenge our hypothesis, we subsequently investigated if high glycolytic activity and dependency on glucose may offer opportunities for counteracting radioresistance of TrC1 AKT-E17K cells

However, once they surpass their physiological concentrations, ROS subject cells to oxidative stress and viciously interact with cellular proteins, carbohydrates, nucleic acid, and lipids, resulting in DNA and protein damage and lipid peroxidation [24] (Fig