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1e, Extended Data Fig

Haffner SM

10.1016/0006-2952(94)90053-1 135 MitchellJ

Clin Exp Rheumatol (2021) 39(1):112

Glucuronidase-cleavable linkers: Activated by -glucuronidase enzymes found in tumor microenvironments and necrotic tissue

The mTOR complexes, mTORC1 and mTORC2, are pivotal regulators of cancer cell metabolism by integrating nutrient availability with signals that drive cell growth and proliferation (Fig