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The clinical therapies applied in ALI/ARDS mainly include pulmonary protective ventilation and limited fluid management supplemented by glucocorticoids, inhaled pulmonary vasodilators, neuromuscular block, and extracorporeal membrane oxygenation (Liu et al., 2022)

128 To facilitate mitochondrial DNA repair, all the proteins necessary for this process must be imported from the cytoplasm because mtDNA does not encode them

This study used another high throughput screening platform to reveal antagonism of muscarinic receptors as a pharmacological means of potentially enhancing remyelination