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10.1186/s12974-023-02890-y J Neuroinflammation

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Curcumin protects MPTP-induced loss of TH-positive neurons and DA depletion in the striatum of MPTP-induced mouse models, as well as a reduction in cytokines, total nitrite, and inflammatory markers such inducible nitric oxide synthase (Ojha et al., 2012)

The differential expression patterns observed in human datasets refer to alterations in the expression of key cuproptosis-related genes, such as FDX1, LIAS, DLAT, pyruvate dehydrogenase E1 subunit 1 and ATP7B, in the brains of patients with AD compared with age-matched healthy controls (213,268,269)

Most proteins were engaged with reaction to push (for example antioxidative proteins, heat shock proteins) and general metabolic cycles (for example glycolysis, ATP supply)

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