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Description

In the context of ADCs, disulfide linkers serve as a critical bridge connecting the cytotoxic drug to the antibody that targets specific cancer cells

Changing the length of the trigger internal loop (that is, the length of the target fragment bridging the two paired regions of the target site), and thereby presumably altering the distal miRNAtrigger duplex trajectory, substantially reduced ZSWIM8 binding and polyubiquitylation (Extended Data Fig