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Aside from that, the thickness of the granular cell layer appeared to decrease

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Furthermore, as it will be further discussed, we have reported a neuroprotective role for IGFs associated to mitochondrial protection and antioxidant defenses in aging animals[5558]

Thus, the gastroprotective effects of melatonin and its precursor L-tryptophan could be attributed to the increase of plasma and gastric mucosal levels of melatonin that probably stimulated the production of NO by the mucosa and increased mucosal microcirculation, both contributing to the reduction of WRS-induced mucosal damage

We are grateful for Daystar University through the Department of Research, Publication & Consultancy for funding this research project