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For example, the efflux Na + /Ca 2+ exchanger restricts mitochondrial Ca 2+ accumulation, promotes cytosolic oscillations in Ca 2+ and contributes to insulin release in MIN6 -cells to a minor degree (Nita et al., 2012)

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[Google Scholar] NapA mediates a redox regulation of the antioxidant response, carbon utilization and development in Aspergillus nidulans

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Too high (hyperpolarization): excess ROS from electron/proton leak (his over-spinning)