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Physiologically, consumption of a high-protein meal or pregnancy can cause hyperfiltration [30]

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In certain embodiments, any controlled-release otic formulation described herein increases the exposure time of an active agent and decreases the C max in otic fluids (e.g., endolymph and/or perilymph) by about 40%, about 30%, about 20%, or about 10%, compared to a formulation that is not a controlled-release otic formulation

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Similar to EpCAM, c-Met also has a putative role in the acquisition of the stem cell status and EMT in cancer that causes tumor cell dissociation and metastasis [154]

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