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However the constructed mutants showed lower levels of GshF expression

Hypermethylation of mitochondrial cytochrome b and cytochrome c oxidase II genes with decreased mitochondrial DNA copy numbers in the APP/PS1 transgenic mouse model of Alzheimer's disease

In fact, Nrf2 regulates the expression of many antioxidant protection genes in the liver

Accordingly, synaptic oxidative stress induced by low pH o might underlay irreversible impairment of synaptic transmission which is a poorly investigated consequence of brain ischemia (Hofmeijer and van Putten2012)